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KMID : 0363620060270040191
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 4 p.191 ~ p.197
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Anti-depressant Effect of Chilbokum under the Forced Swimming Test in Rats
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Shim In-Sop
Kim Jung-Ki
Koo Byung-Soo
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Abstract
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Objectives : The aim of this study was to evaluate the anti-depressant effect of Chilbokum on rats under the forced swimming test (FST)
Methods : The rats were treated with the herbal extract, Chilbokum. In order to induce depression-like symptoms, the FST was conducted afterwards. The immobility time was measured during a 5-min experimental session. The alterations of the 5-HT level in the hypothalamus and hippocampus and the change of corticosterone level in the blood induced by FST were determined in the rats.
Results : The results were as follows: 1. The immobility time during 5 min of FST in the drug administration group showed significant decreases compared with the control group (p<0.05). 2. The FST+Chilbokum group had significantly increased 5-HT levels of the hypothalamus and hippocampus, compared with the control group (p<0.05, respectively). 3. The FST+Chilbokum group had significantly decreased corticosterone levels, compared with the control group (p<0.05).
Conclusions : These results demonstrate that the reduced immobility time by Chilbokum may be mediated by the increase in 5-HT level in the hypothalamus and hippocampus, suggesting that Chilbokum has a potential therapeutic efficacy for human depression.
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KEYWORD
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Chilbokum, anti-depressant effect, forced swimming test (FST), 5-HT, corticosterone
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